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MessagePosté le: Mer 11 Juil - 09:59 (2018)    Sujet du message: on Monday Répondre en citant

LONDON cheap adidas tubular , Aug. 2 (Xinhua) -- A team of researchers has successfully corrected a disease-causing gene mutation in human embryos by using a gene-editing tool, stopping it from passing to future generations, according to a study published Wednesday in the journal Nature.

The new method uses the gene-editing tool CRISPR to target a mutation in nuclear DNA that causes hypertrophic cardiomyopathy, a common genetic heart disease condition which can cause sudden cardiac death and heart failure.

Hypertrophic cardiomyopathy affects an estimated one in 500 people and can lead to heart failure and sudden death.

Researchers worked with healthy donated human oocytes (cell) in ovaries that form an ovum] and sperm carrying the genetic mutation that causes cardiomyopathy. Embryos created in this study were used to answer pre-clinical questions about safety and effectiveness.

"Every generation would carry on this repair because we've removed the disease-causing gene variant from that family's lineage," said senior author of the report Shoukhrat Mitalipov cheap adidas stan smith , who directs the Center for Embryonic Cell and Gene Therapy at Oregon Health & Science University.

CRISPR, which stands for clustered regularly interspaced short palindromic repeats, holds promise for correcting mutations in the human genome to prevent genetic disease.

The gene-editing technique, done in concert with in vitro fertilization (IVF), could provide a new avenue for people with known heritable disease-causing genetic mutations to eliminate the risk of passing the disease to their children. It could also increase the success of IVF by increasing the number of healthy embryos.

The study is "the first to show successful and efficient correction of a disease-causing mutation in early stage human embryos with gene editing cheap adidas superstar 80s ," said Dr Yalda Jamshidi from St George's, University of London.

However, the team also noted that genome editing approaches must be "further optimized" before moving to clinical trials.

WASHINGTON, Oct. 10 (Xinhua) -- While tightening global monetary policies would put more pressure on short-term liquidity in frontier markets (FMs), Chinese financing could help mitigate liquidity risk for these countries cheap adidas superstar flowers , said Moody's, a ratings agency, in a report released on Monday.

Moody's defines FMs as sub-investment-grade countries that rely heavily on concessional financing. Moody's rates 36 FM countries, most of which carry ratings in the B1-B3 range.

"Benign global liquidity conditions have permitted some FMs to raise commercial U.S. dollars sovereign debt, at relatively favorable rates cheap adidas superstar supercolor ," Anne Van Praagh, a Moody's Managing Director, said. "One quarter of FMs had issued new debt on commercial terms as of August 2017."

"Looking ahead, as global liquidity conditions evolve, elevated debt service costs and liquidity risks are key credit challenges for FMs cheap adidas superstar slip on ," she added.

The most vulnerable sovereigns are those with larger external vulnerabilities, limited domestic fiscal policy space, high gross borrowing needs and low institutional strength, the report said.

Higher global interest rates could limit market access and significantly raise debt servicing costs for sovereigns with a material proportion of externally financed debt and large gross borrowing requirements.

According to the report, liquidity risks are most acute in Egypt cheap adidas superstar foundation , Pakistan and Mongolia.

"Financing from China through foreign direct investment and swap line arrangements has become more important for some FMs, 16 of which are listed under China's Belt and Road Initiative," said the report.

"Chinese financing could help mitigate near-term liquidity risks," said the report.

"It is encouraging a shift away from financing by international financial institutions, which have historically provided a stable funding source cheap adidas neo shoes , including on concessional terms."

RIO DE JANEIRO, April 24 (Xinhua) -- China's Hui Zicheng set a world record to win the men's 50m rifle 3 positions gold medal at the ISSF World Cup stage in Rio de Janeiro on Sunday.

Hui survived a late challenge from the USA's Matthew Emmons to register a final score of 463.7 points, beating the previous record set by Russia's Nazar Louginetsin in 2014.

Emmons pocketed silver with 461.6 points while China's Zhu Qinan clinched the bronze medal with 451.2 points.

Hui's victory took China's medal tally at the Rio 2016 Olympic test event to seven (two gold, two silver and three bronze), making them the most successful team of the 10-day competition, which concluded on Sunday.

Russia was next on the medals table with 2-2-1, followed by Ukraine 2-0-1.

In Sunday's only other event, Sweden's Marcus Svensson won the men's skeet gold medal.

Svensson held his nerve in a tense playoff in the final against India's Mairaj Ahmad Khan. Italy's Cassandro Tammaro was third.
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